Response of peripheral venous pressure and plasma catecholamine concentration to supine leg exercise. A study in patients with mild congestive heart failure.

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Abstract
We measured the peripheral venous pressure (VP) in supine leg exercise in 25 "normal" subjects and 122 patients with primarily left-sided heart diseases (NYHA class I = 68, class II = 54 cases) to determine whether or not plasma catecholamine concentration would increase in patients with mild congestive heart failure, in response to dynamic exercise. Cardiac patients (n = 122) were divided into 2 groups on the basis of VP increment (.DELTA.VP): Group N had 60 patients with .DELTA.VP less than 35 mm H2O, and Group H had 62 patients with .DELTA.VP in excess of 35 mmH2O. Plasma concentrations of noradrenaline (NA) and adrenaline (A) were measured before and during leg exercise. The relation between .DELTA.VP, NA and A, and the relation between .DELTA.VP and increments of NA (.DELTA.NA) and of A (.DELTA.A) by leg exercise were studied in both the cardiac patients and the "normal" subjects (Group C). (1) NA at rest was 0.225 .+-. 0.016 ng/ml (mean .+-. SE) in Group C and 0.216 .+-. 0.009 ng/ml in Group N. It was 0.468 .+-. 0.026 ng/ml in Group H, which was significantly higher than in Group C (p < 0.001), or Group N (p < 0.001). (2) .DELTA.NA was 0.051 .+-. 0.009 ng/ml (mean .+-. SE) in Group C, 0.067 .+-. 0.007 ng/ml in Group N, and 0.249 .+-. 0.019 ng/ml in Group H. There was a statistically significant difference in .DELTA.NA between Groups C and H (p < 0.001) and between Groups N and H (p < 0.001). (3) There was no significant difference between the three groups in A at rest, or in .DELTA.A. (4) There was a correlation between .DELTA.VP and NA at rest (r = 0.614, p < 0.001) and between .DELTA.VP and .DELTA.NA (r = 0.708, p < 0.001). These data suggest that sympathetic nervous activity increased in the patients with high .DELTA.VP but without overt heart failure, and that the constriction of the capacitance vessels caused by an increase in NA could be at least one of the mechanisms involved in raising the .DELTA.VP in those patients.