Antithrombin III in Fresh Frozen Plasma, Cryoprecipitate, and Cryoprecipitate‐depleted Plasma

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Abstract
Antithrombin (AT)III is a plasma protein that inhibits several activated procoagulants. Hereditary disease or acquired conditions such as severe hepatic dysfunction, nephrotic syndrome and intravascular coagulation may be associated with reduced levels of AT III. Its replacement may be essential in controlling thrombosis. To determine the most effective form of replacement, AT III [human] biological activity and antigen levels were compared in conventionally prepared fresh frozen plasma, cryoprecipitate and cryoprecipitate depleted plasma (CDP). The activity and antigen levels were comparable in all 3 products (approximately 100%) and AT III was not concentrated in cryoprecipitate. Conventionally prepared CDP, fresh frozen plasma and cryoprecipitate contain equal quantities vol/vol of AT III. All products were equally effective as therapy for AT III deficiency, but CDP and fresh frozen plasma were recommended as convenient sources of this factor.

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