Complexation of several drugs with water-soluble cyclodextrin polymer.
- 1 January 1987
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 35 (1) , 282-288
- https://doi.org/10.1248/cpb.35.282
Abstract
The complex-forming abilities of a water-soluble .beta.-cyclodextrin-epichlorohydrin polymer (CDPS) and two different molecular weight fractions of CDPS were studied and compared with those of .beta.-cyclodextrin (.beta.-CyD) and dimethyl-.beta.-cyclodextrin (DM-.beta.-CyD). CDPS was separated into two main fractions by gel chromatography. CDPS and its fractions formed inclusion compounds with several drugs and these complexes were readily soluble. The low-molecular-weight fraction formed rather stable complexes with small guest molecules. The high-molecular-weight fraction was found to be more efficient in binding larger substrates.This publication has 5 references indexed in Scilit:
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