Cytotoxic hybrid molecules ‘metalloporphyrin–ellipticine’ having a high affinity for DNA
- 1 January 1989
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 22,p. 1711-1713
- https://doi.org/10.1039/c39890001711
Abstract
Hybrid molecules ‘cationic metalloporphyrin–intercalators’ have been synthesized which have a high affinity for double-stranded DNA and are able to cleave it at low concentrations; compound (2), an efficient bleomycin model based on a cationic metalloporphyrin, is cytotoxic towards murine leukaemia cells L1210 in vitro; iron and zinc analogues of (2) are less active, despite having the same affinity for nucleic acids.Keywords
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