Radiolabeling of Methylphosphonate and Phosphorothioate Oligonucleotides and Evaluation of Their Transport in Everted Rat Jejunum Sacs
- 1 January 1995
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 12 (6) , 817-824
- https://doi.org/10.1023/a:1016296617434
Abstract
Purpose. The therapeutic use of antisense oligonucleotides will likely involve their administration over protracted periods of time. The oral route of drug dosing offers many advantages over other...Keywords
This publication has 27 references indexed in Scilit:
- Human intestinal cell line Caco-2: a useful model for studying cellular and molecular regulation of biotin uptakeBiochimica et Biophysica Acta (BBA) - Biomembranes, 1994
- Cationic Lipids Improve Antisense Oligonucleotide Uptake and Prevent Degradation in Cultured Cells and in Human SerumBiochemical and Biophysical Research Communications, 1993
- Current concepts in antisense drug designJournal of Medicinal Chemistry, 1993
- Strategies for administering targeted therapeutic oligodeoxynucleotidesTrends in Biotechnology, 1992
- Molecular-Weight-Dependent Pharmacokinetics of Fluorescein-Labeled Dextrans in RatsJournal of Pharmaceutical Sciences, 1992
- Cellular uptake and intracellular fate of antisense oligonucleotidesTrends in Cell Biology, 1992
- Therapeutic Applications of OligonucleotidesAnnual Review of Pharmacology and Toxicology, 1992
- Absorption and Metabolic Characteristics of p-Aminobenzoic Acid and Its Isomer, m-Aminobenzoic Acid, from the Rat Small IntestineJournal of Pharmaceutical Sciences, 1991
- Time-dependent deterioration of active transport in duodenal segments of rat intestineJournal of Pharmacological Methods, 1988
- Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genesPublished by Elsevier ,1988