Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors
- 1 January 2000
- journal article
- clinical trial
- Published by Springer Nature in Journal of NeuroVirology
- Vol. 6 (1) , 84-88
- https://doi.org/10.3109/13550280009006385
Abstract
A study of neuropsychological performance was conducted in 33 HIV+ patients initiating highly active antiretroviral therapy (HAART). Grooved Pegboard (GP) non-dominant hand performance improved in 23/33 (70%) subjects (P=0.002). Among 23 patients with motor slowing (GP non-dominant hand z score < -1.0) at baseline, 18 (78%) improved on the GP non-dominant hand test after initiating HAART (P=0.001). GP non-dominant hand performance improved longitudinally in HIV+ patients initiating HAART, while matched HIV+ controls not on HAART did not change (P=0.045). Significant improvement in motor performance can occur after HAART in HIV+ patients with impairment.Keywords
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