Effect of chlorpromazine on intestinal absorption of sulfamethoxazole in rats.

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Abstract
The effect of chlorpromazine (CPZ) [a tranquilizer] on the intestinal absorption of sulfamethoxazole (SMZ) [an antibacterial drug] was studied in isolated perfused rat small intestine by comparing 2 determinants, i.e., the epithelial permeability and the intestinal blood flow. The appearance rate of SMZ in blood in the presence of CPZ decreased to 1/2 of the control without CPZ. The pH of perfusion solution was significantly decreased by CPZ after 10 min perfusion. According to the Winne''s absorption model, CPZ did not change the apparent epithelial permeability of SMZ, but decreased the epithelial permeability of unionized SMZ due to the decrease in the pH of perfusion solution by CPZ. CPZ apparently decreased the fraction of the total blood flow rate in the subepithelial capillaries to less than 1/2 .