Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis
- 18 February 1997
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 94 (4) , 1172-1176
- https://doi.org/10.1073/pnas.94.4.1172
Abstract
To identify novel antiapoptotic proteins encoded by DNA viruses, we searched viral genomes for proteins that might interfere with Fas and TNFR1 apoptotic signaling pathways. We report here that equine herpesvirus type 2 E8 protein and molluscum contagiosum virus MC159 protein both show sequence similarity to the death effector domains (DEDs) of the Fas/TNFR1 signaling components FADD and caspase-8. Yeast two-hybrid analysis revealed that E8 protein interacted with the caspase-8 prodomain whereas MC159 protein interacted with FADD. Furthermore, expression of either E8 protein or MC159 protein protected cells from Fas- and TNFR1-induced apoptosis indicating that certain herpesviruses and poxviruses use DED-mediated interactions to interfere with apoptotic signaling pathways. These findings identify a novel control point exploited by viruses to regulate Fas- and TNFR1-mediated apoptosis.Keywords
This publication has 58 references indexed in Scilit:
- FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling ComplexCell, 1996
- Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell DeathCell, 1996
- ICE Family Proteases: Mediators of All Apoptotic Cell Death?Immunity, 1996
- Molecular Ordering of the Cell Death Pathway: Bcl-2 AND Bcl-xL FUNCTION UPSTREAM OF THE CED-3-LIKE APOPTOTIC PROTEASESPublished by Elsevier ,1996
- Inhibition of the Caenorhabditis elegans cell-death protease CED-3 by a CED-3 cleavage site in baculovirus p35 proteinNature, 1995
- The Baculovirus p35 Protein Inhibits Fas- and Tumor Necrosis Factor-induced ApoptosisPublished by Elsevier ,1995
- The DNA Sequence of Equine Herpesvirus 2Journal of Molecular Biology, 1995
- Fas and Perforin Pathways as Major Mechanisms of T Cell-Mediated CytotoxicityScience, 1994
- T2 open reading frame from the shope fibroma virus encodes a soluble form of the TNF receptorBiochemical and Biophysical Research Communications, 1991
- Activation of Epstein–Barr virus latent genes protects human B cells from death by apoptosisNature, 1991