Oligoclonal Immunoglobutins, Light Chain Ratios and Free Light Chains in Cerebrospinal Fluid and Serum from Patients Affected with Various Neurological Diseases

Abstract
Several immunological parameters, of which the most important are the .kappa.-.lambda. ratios, the presence of free L-chains and the double ring formation for .kappa.-chains in single radial immunodiffusion, were investigated in the CSF and serum of patients affected with different neurological diseases. Parallels were run with multiple sclerosis or subacute sclerosing panencephalitis. There may be a correlation between the frequency of the presence of free L-chains and the degree of severity of the immunological process.

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