Effects of Acid in Stomach and Duodenum upon the Gastric Myoelectrical Activity in Man

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Abstract
The period of the pacesetter potentials (PP) in the normal human stomach was studied when infusing HCl (75 mEq/l) or saline in the stomach or duodenum. When a 350-ml volume of saline was infused into the stomach, an 11 % increase of the PP period was observed. With 350 ml of acid solution, the maximum increase was 40%. This occurred 8 min after the onset of infusion, at the moment when the serum gastrin level was significantly lowered. When the acid solution was infused into the duodenum, a flow rate of acid dependent increase of the PP period occurred (43% with 4 ml/min). Saline induced no change. A single intravenous injection of secretin (0.5 U/kg) induced an increase in the PP period whose maximum (35%) occurred 4 min after the injection. The results suggest that gastric myoelectrical activity may be affected by a hormonal regulation in which endogenous secretin and gastrin would determine opposite responses.

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