Effect of aging on 6-keto-PGF1.ALPHA. levels in normotensive and essential hypertensive males.
- 1 January 1983
- journal article
- research article
- Published by Japanese Circulation Society in Japanese Circulation Journal
- Vol. 47 (3) , 309-312
- https://doi.org/10.1253/jcj.47.309
Abstract
Prostacyclin (PGI2) is produced in the vessel wall and acts as a vasodilator hormone. Measurement of plasma 6-keto-PG[prostaglandin]F1.alpha. is considered to be an index of PGI2 production. The effects of aging on the plasma 6-keto-PGF1.alpha. levels were studied in 64 normotensive and 48 essential hypertensive [human] males. The subjects were divided into 3 groups, i.e., young (24-39 yr), middle-aged (40-55 yr) and elderly (> 56 yr) groups. Plasma 6-keto-PGF1.alpha. was measured by specific radioimmunoassay after silicic acid column chromatographic purification. The 6-keto-PGF1.alpha. levels were lower in elderly normotensive males (10.3 .+-. 1.4 pg/ml, mean .+-. SE, n = 12) than in normotensive young males (15.3 .+-. 2.3, n = 30, P < 0.05). The plasma 6-keto-PGF1.alpha. levels in hypertensive elderly males (10.6 .+-. 1.3 pg/ml, n = 10) is lower than in hypertensive young males (19.8 .+-. 2.2, n = 17, P < 0.01). Apparently, the plasma 6-keto-PGF1.alpha. levels decreased with age in normotensive and hypertensive groups. Thus, PGI2 production may decrease with age.This publication has 2 references indexed in Scilit:
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