Lymphocytosis-Promoting Factor of Bordetella pertussis: Isolation, Characterization, and Biological Activity

1 August 1977

journal article
research article
Published by Oxford University Press (OUP) in The Journal of Infectious Diseases

Vol. 136 (Supplement) , S234-S238
https://doi.org/10.1093/infdis/136.supplement.s234

Abstract

The leukocytosis and lymphocytosis-promoting factor (LPF) of Bordetella pertussis has been isolated in apparently pure form. LPF is a protein essentially free of lipid and carbohydrate with an estimated molecular weight of 67,000-73,600 daltons, Purified LPF induced both histamine sensitization and refractoriness to epinephrine-induced hyperglycemia and was a murine thymus-derived (T-) cell mitogen. Adenyl cyclase activity also appeared to be associated with LPF.

Keywords

EPINEPHRINE
PROMOTING FACTOR
REFRACTORINESS
PROTEIN
BORDETELLA PERTUSSIS
LYMPHOCYTOSIS
MITOGEN
ADENYL