Light-Directed Radial Combinatorial Chemistry: Orthogonal Safety-Catch Protecting Groups for the Synthesis of Small Molecule Microarrays
- 1 December 2004
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (51) , 16704-16705
- https://doi.org/10.1021/ja044702q
Abstract
We describe the development of photolabile protecting groups based on the 3,4,5-trimethoxyphenacyl group (TMP). Orthogonal safety-catches were created by introducing an acid-activatible dimethyl ketal (AA-TMP) and an oxidatively activatible 1,3-dithiane (OA-TMP) into the photolabile TMP group. We demonstrate the application of these protecting groups in light-directed synthesis of small molecule microarrays with diversity elements radially attached to a hydroxyproline scaffold.Keywords
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