Polyomavirus middle T antigen downregulates junctional cell-to-cell communication.
Open Access
- 1 February 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (2) , 946-950
- https://doi.org/10.1128/mcb.7.2.946
Abstract
We examined the effect of polyomavirus middle T antigen on cell-to-cell communication in rat F cells transfected with an inducible middle T recombinant DNA or infected with a conditional mutant virus. Junctional permeability fell (reversibly) when middle T transcription was induced or when middle T was switched to the transformation+ form. The effect correlates with the rise of protein tyrosine kinase activity.This publication has 41 references indexed in Scilit:
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