HIGH-AFFINITY OF NONESTERIFIED POLY-UNSATURATED FATTY-ACIDS FOR RAT ALPHA-FETOPROTEIN (AFP)

  • 1 January 1980
    • journal article
    • research article
    • Vol. 1  (1) , 27-36
Abstract
A mixture of nonesterified long chain fatty acids, mainly polyunsaturated, which are extracted under certain conditions from either whole mammalian sera or from pure rat alpha1-fetoprotein (AFP), interferes with rat AFP-estrogen interaction. A quantitative study of the Ka for the binding to AFP of these different fatty acids is presented. Important differences among them, the polyunsaturated ones displaying higher Ka (Ka .apprx. 107 to 108 M-1) than the monounsaturated (Ka .apprx. 106 M-1) or the saturated (Ka .apprx. 104 to 105 M-1) compounds are presented. Though all the fatty acids identified in rat serum or rat AFP extract are more or less tightly bound by rodent AFP, only some of them can compete for exogeneous estrogens complexed to this highly estrophilic macromolecule.

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