Studies on Immunizing Substances in Pneumococci: XII. Comparison of the Effect of Whole-Cell Vaccine and of Polysaccharide Antigen in Human Beings

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Abstract
The relative antigenicity of pneumococcus whole-cell vaccine and polysaccharide antigen as indicated by serum-antibody and skin-test reaction was detd. in a group of ambulatory patients. No significant difference was found in protective titer of the sera. Individual variation in response occurred with both alike. Certain individuals were unable to manufacture antibody to vaccine given in 1-2 injns. 14 days apart, as has been found in the case of polysaccharide antigen. In general, 2 injns. of either at this interval and in the dose used were not followed by increased serum antibody. There were more skin-positive individuals among those immunized with polysaccharide antigen than with whole-cell vaccine.

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