Practical Assessment of the NBT-PABA Pancreatic Function Test Using High Performance Liquid Chromatography Determination of P-Aminobenzoic Acid in Urine

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Abstract
A practical method for determining p-aminobenzoic acid in urine by high-performance liquid chromatography has been assessed. The technique is quick, requires no extraction steps and has good precision. Using this method, healthy individuals had a p-aminobenzoic acid excretion index of 94% ±18 (mean±1 SD). Patients with proven, severe chronic exocrine pancreatic dysfunction had index values of <5–25%. Unlike chemical methods available, there were no interferences in any of the urines tested, nor did 12 compounds tested interfere with the analysis.