COMPARISON OF THE THERAPEUTIC RESPONSE OF PATIENTS WITH CHILDHOOD ACUTE LYMPHOBLASTIC-LEUKEMIA IN RELAPSE TO VINDESINE VERSUS VINCRISTINE IN COMBINATION WITH PREDNISONE AND L-ASPARAGINASE - A PHASE-III TRIAL

  • 1 January 1981
    • journal article
    • research article
    • Vol. 65  (11-1) , 1015-1019
Abstract
A total of 179 previously treated children with acute lymphoblastic leukemia in relapse considered not resistant to vincristine (VCR) were randomly allocated to receive reinduction therapy with vindesine (VND) or VCR, in combination with prednisone and L-asparaginase. Complete remission rates were 57% for both regimens and were significantly greater for 1st relapsers (69%) than for subsequent relapsers (43%). No significant difference in response rates by regimen was observed within relapse groups. Patients treated with VND experienced significantly greater hematologic toxicity. There probably is no advantage to using VND instead of VCR in standard reinduction therapy for childhood acute lymphoblastic leukemia in relapse.

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