DNA sequence of the coding region of the HLA-B44 gene
- 1 June 1986
- journal article
- research article
- Published by Springer Nature in Immunogenetics
- Vol. 23 (6) , 396-400
- https://doi.org/10.1007/bf00372673
Abstract
An HLA-B44 cDNA clone was identified in a cDNA library constructed from an HLA-B44 homozygous cell line. The DNA sequence was determined and was found to contain the complete coding sequence but for (probably) the three N-terminal codons. Comparisons of the derived amino acid sequence with other HLA-A and -B locus amino acid sequences revealed four HLA-B44-specific substitutions including a new polymorphic site. Regions of strong sequence conservation for HLA-B-locus products were found at the nucleotide and amino acid levels.Keywords
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