IMMUNOGENICITY OF CHEMICALLY-INDUCED MURINE COLON CANCERS
- 1 January 1979
- journal article
- research article
- Vol. 39 (4) , 1174-1179
Abstract
The antigenicity and immunogenicity of 3 colorectal carcinomas induced in BALB/c mice by 1,2-dimethylhydrazine or N-methyl-N-nitrosourethan were studied. All tumors were readily transplantable. Of these tumors, 2 metastasized when transplants reached sufficient size. All tumors were immunogenic in the strain of origin, and all tumors contain unique tumor-specific transplantation antigens in cross-protection experiments. The use of these tumors as an animal model for studies of adjuvant immunotherapy and chemoimmunotherapy is suggested.This publication has 6 references indexed in Scilit:
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