1,25-Dihydroxycholecalciferol stimulation of a mitochondrial protein in chick intestinal cells

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Abstract
The steroid hormone 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) stimulates the absorption of dietary Ca by the small intestine of animals although the exact mechanism by which this is achieved remains unclear. It was long known that a soluble, Ca-binding protein (CaBP), is produced in large amounts in the cytoplasm of the intestinal cells of animals after in vivo administration of vitamin D3 or 1,25-(OH)2D3. 1,25-(OH)2D3 administered in vivo to rachitic chickens also stimulates production of another protein with MW 39,000-42,000 which is insoluble in the absence of detergent, found in the outer mitochondrial membrane and produced in advance of maximum Ca transport.