Spectrophotometric Method for Assay of Serum Antiprotease: Clinical Applications.

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Abstract
A spectrophotometric method (Coleman Spectrophotometer, Model 14, set at 675 m[mu]) of assay of antiproteolytic material in the serum, using inhibition of trypsin digestion of fibrinogen, is descr. Tests were performed on 250 samples of blood from patients with various diseases and from control patients without evident disease. Using a normal control at 100%, an antiproteolytic titer below 103% could be considered negative (5% possible error), and a titer above 130% as indicative of malignant neoplasia (5% possible error). Titers between 103% and 130% must be considered as of doubtful significance. These results are comparable to those obtained by a previously descr. clot formation method.

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