Role of Thiamin (Vitamin B-1) and Transketolase in Tumor Cell Proliferation
- 1 March 2000
- journal article
- review article
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 36 (2) , 150-154
- https://doi.org/10.1207/s15327914nc3602_2
Abstract
Metabolic control analysis predicts that stimulators of transketolase enzyme synthesis such as thiamin (vitamin B-1) support a high rate of nucleic acid ribose synthesis necessary for tumor cell survival, chemotherapy resistance, and proliferation. Metabolic control analysis also predicts that transketolase inhibitor drugs will have the opposite effect on tumor cells. This may have important implications in the nutrition and future treatment of patients with cancer.Keywords
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