ARTHROGRYPOSIS

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Abstract
Three typical cases of arthrogryposis are presented. Neurological examination points to involvement of the central nervous system in this illness. Repeated muscle biopsies in all 3 patients and a complete post-mortem examination in 1, suggest that this may be an infantile form of neuromuscular atrophy rather than a primary disease of either the joints or the muscles. Neither the use of steroid therapy nor prostigmine produced lasting benefits, although ACTH did seem to produce a definite, though slight, effect in freeing motion in the smaller, peripheral joints. One patient may have benefited from application of rehabilitation techniques.

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