DISPLACEMENT BY METIAMIDE OF THE DOSE‐RESPONSE CURVES TO PENTAGASTRIN AND METHACHOLINE IN THE CONSCIOUS RAT
Open Access
- 1 August 1975
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 54 (4) , 507-509
- https://doi.org/10.1111/j.1476-5381.1975.tb07598.x
Abstract
1 The effect of a specific histamine H2-receptor antagonist, metiamide, on the acid dose-response curves for pentagastrin or methacholine was studied in rats provided with Heidenhain pouches. 2 Metiamide induced a shift to the right of the dose-response curve to pentagastrin and lowered the maximal secretion. 3 In contrast, metiamide only increased the ED50 for methacholine but did not alter the calculated maximal response. 4 The effect of metiamide on pentagastrin and methacholine-induced secretion is in agreement with the previously suggested difference in the part played by mucosal histamine in the mode of action of the two stimulatory agents.Keywords
This publication has 11 references indexed in Scilit:
- Elicidation by a H-2-receptor antagonist of the significance of mucosal histamine mobilization in exciting acid secretion.The Journal of Physiology, 1975
- Histamine metabolism of the gastric mucosa following antrectomyThe Journal of Physiology, 1974
- Alterations in secretory patterns following vagotomy in rats with Pavlov or Heidenhain pouchesThe Journal of Physiology, 1973
- Metiamide — An orally active histamine H2-receptor antagonistInflammation Research, 1973
- Gastric secretion and its facilitation as related to gastric mucosal histamineThe Journal of Physiology, 1972
- Definition and Antagonism of Histamine H2-receptorsNature, 1972
- The secretory pattern of three stomach preparations in the ratThe Journal of Physiology, 1970
- The role of the antrum and the vagus nerve in the formation of gastric mucosal histamineThe Journal of Physiology, 1969
- A Comparison of Estimates of Michaelis-Menten Kinetic Constants from Various Linear TransformationsJournal of Biological Chemistry, 1965