Effects of Morphine on Spontaneous Activity of 18-Day Rat Fetus
- 1 January 1979
- journal article
- research article
- Published by S. Karger AG in Developmental Neuroscience
- Vol. 2 (5) , 238-244
- https://doi.org/10.1159/000112486
Abstract
The effects of morphine on spontaneous activity of 18-day fetal rats have been observed in utero. Morphine injected subcutaneously in the dam caused a decrease in fetal spontaneous activity which was dose-dependent. The maximum depression of activity occurred after 20 mg/kg was administered to the dam. Activity returned to control levels following naloxone administration to the dam. Fetuses which had been chronically exposed to morphine from days 7 through 17 and observed on day 18 of gestation became hyperactive following administration of naloxone to the dam. This is thought to represent fetal withdrawal.Keywords
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