Relaxation of carbocyclic thromboxane A2-induced contractions of isolated coronary arteries by nifedipine
- 1 January 1982
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 318 (3) , 249-251
- https://doi.org/10.1007/bf00500488
Abstract
± Carbocyclic thromboxame A2 (2.9×10−7 mol/l) contracted isolated rings of cat coronary artery. These contractions could be partly inhibited by low concentrations of nifedipine (50% inhibitory concentration —IC50=6.8×10−8 mol/l) and completely relaxed by papaverine. Relaxation of thromboxane-induced coronary spasm may contribute to the effectiveness of calcium antagonists in variant angina, which may be caused or exacerbated by thromboxane A2 release from platelets.Keywords
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