Rearrangements of penicillin sulphoxides
- 1 January 1970
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications
- No. 17,p. 1059-1060
- https://doi.org/10.1039/c29700001059
Abstract
Isomerisation of a penicillin G (R)-sulphoxide into the corresponding (S)-isomer proceeds by a sulphenic acid intermediate which has been trapped by deuterium incorporation; in the rearrangement of the t-butylamides of the (S)-sulphoxide of penicillin G only cepham and penam derivatives are isolated and no cephem products are formed.Keywords
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