Abstract
A wealth of evidence suggests that pathogens may play a role--perhaps even a causal one--in chronic diseases like Alzheimer9s or MS. Proving that theory, however, is another matter. Every step of the research is fraught with controversy, from isolating the pathogens to determining how they might cause the disease to sorting out how a host9s genetic profile influences the course of disease. And because these illnesses are chronic, scientists have to confront frustrating questions about cause and effect that don9t come up with acute illnesses like Ebola or the mumps.

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