POLYMORPHISM OF THE TUMOUR NECROSIS FACTOR BETA GENE IN MULTIPLE SCLEROSIS AND RHEUMATOID ARTHRITIS
- 1 October 1994
- journal article
- Published by Wiley in European Journal of Immunogenetics
- Vol. 21 (5) , 377-382
- https://doi.org/10.1111/j.1744-313x.1994.tb00208.x
Abstract
We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF-beta*2 allele was observed in HLA-DR2+ vs. HLA-DR2- MS patients. No such association was seen in HLA-DR4+ RA patients.Keywords
This publication has 20 references indexed in Scilit:
- Map of the human MHCImmunology Today, 1993
- HLA Haplotype Sharing in Rheumatoid Arthritis Sibships: Risk Estimates in SiblingsScandinavian Journal of Rheumatology, 1992
- HLA class II‐associated genetic susceptibility in multiple sclerosis: A critical evaluationTissue Antigens, 1991
- Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.The Journal of Experimental Medicine, 1991
- Tumor necrosis factor alpha gene polymorphism in multiple sclerosis and optic neuritisJournal of Neuroimmunology, 1990
- The Biology Of Cachectin/TNF: A Primary Mediator Of The Host ResponseAnnual Review of Immunology, 1989
- The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisArthritis & Rheumatism, 1988
- HLA class II induction in human islet cells by interferon-γ plus tumour necrosis factor or lymphotoxinNature, 1987
- New diagnostic criteria for multiple sclerosis: Guidelines for research protocolsAnnals of Neurology, 1983
- Multiple Comparisons Among MeansJournal of the American Statistical Association, 1961