Measurement of dissolution rates of potassium chloride from various slow release potassium chloride tablets using a specific ion electrode

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Abstract
The in vitro rates of release of potassium ions from slow-release potassium chloride tablets from 12 sources have been compared. Dissolution rates were determined using a modified non-sink method and a modified sink method. Medicament release in both methods was continuously monitored using a potassium ion specific electrode. The release rate constants were derived and the applicability of the Noyes-Whitney equation, Hixson and Crowell's cube root law and Higuchi's equation was studied.

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