Sacral Abnormalities in Marfan Syndrome

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Abstract
Five women with Marfan syndrome had abnormalities of the sacrum disclosed by computed tomography. Each had evidence of expansion of the central sacral spinal canal and enlargment of sacral foramina associated with extensive bony erosion. Three patients complained of low back pain; 2 were asymptomatic. Sacral meningoceles were demonstrated in 3 cases (including 2 of the 3 with symptoms). A 4th patient had a thoracic meningocele. The sacral abnormalities are attributed to defective collagen resulting in expansion of weakened dura which leads to pressure erosion of contiguous osseous structures.

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