Tandem silica gel-catalysed rearrangements and subsequent Baeyer–Villiger reactions of artemisinin derivatives
- 1 January 1994
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 7,p. 843-846
- https://doi.org/10.1039/p19940000843
Abstract
Novel silica gel-catalysed reactions of dihydroartemisinin 1b to deoxyartemisinin 11 and 11β-hydroxy-11-epidihydroartemisinin 8 to compound 9 under mild conditions are described. The structures of the products were determined by mass spectrometry and 1D- and 2D-NMR spectroscopy. A mechanism for their formation is proposed.Keywords
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