A possible autocrine role for interleukin-6 in two lymphoma cell lines
Open Access
- 1 August 1989
- journal article
- Published by American Society of Hematology in Blood
- Vol. 74 (2) , 798-804
- https://doi.org/10.1182/blood.v74.2.798.bloodjournal742798
Abstract
Interleukin-6 (IL-6) is a growth factor with diverse biologic activity. Originally described as a T-cell product that enhances immunoglobulin (Ig) secretion in antigen-stimulated B cells, it also affects the growth of T cells, plasmacytomas, hybridomas, and hematopoietic stem cells. We report the expression and secretion of IL-6 by two lymphoma cell lines, OCI-LY3 and OCI-LY12. Addition of recombinant IL-6 stimulated their growth, whereas addition of polyclonal anti- recombinant IL-6 (anti-rIL-6) had a marked inhibitory effect on proliferation. These results suggest an autocrine role for IL-6 in the growth of these lymphoma cells in culture.Keywords
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