A Gradient Signal Orchestrates the Mitotic Spindle
- 26 August 2005
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 309 (5739) , 1334-1335
- https://doi.org/10.1126/science.1117842
Abstract
Assembly of the mitotic spindle is critical for the proper segregation of chromosomes during cell division. In his Perspective, Clarke discusses work by Caudron et al. (in the same issue) that shows how generation at chromosomes of a chemical gradient of Ran-GTP directs microtubule nucleation and growth during spindle assembly. The findings suggest a general principle for the spatial control of intracellular organization.Keywords
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