Immunity againstHelicobacter pylori: Significance of Interleukin-4 Receptor α Chain Status and Gender of Infected Mice
Open Access
- 1 January 2001
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 69 (1) , 547-550
- https://doi.org/10.1128/iai.69.1.556-558.2001
Abstract
Vaccination of interleukin-4 (IL-4) receptor α (IL-4Rα) chain-deficient BALB/c mice withHelicobacter pyloriurease and cholera toxin or with urease-expressing, live attenuatedSalmonella entericaserovar Typhimurium cells revealed that protection againstH. pyloriinfection is independent of IL-4- or IL-13-mediated signals. A comparison of male and female mice suggests a sexual dimorphism in the extent of bacterial colonization that is particularly evident in the absence of the IL-4Rα chain.Keywords
This publication has 16 references indexed in Scilit:
- Therapeutic Oral Vaccination Induces Mucosal Immune Response Sufficient to Eliminate Long-TermHelicobacter pyloriInfectionMicrobiology and Immunology, 2000
- Naturally acquired human immune responses againstHelicobacter pylori and implications for vaccine developmentGut, 1999
- Differences Between IL-4- and IL-4 Receptor α-Deficient Mice in Chronic Leishmaniasis Reveal a Protective Role for IL-13 Receptor SignalingThe Journal of Immunology, 1999
- Immunization of Mice with Urease Vaccine Affords Protection against Helicobacter pylori Infection in the Absence of Antibodies and Is Mediated by MHC Class II–restricted ResponsesThe Journal of Experimental Medicine, 1998
- Immunization of BALB/c mice with Helicobacter urease B induces a T helper 2 response absent in Helicobacter infectionGastroenterology, 1998
- Helicobacter pylori and gastric cancer: what is the real risk?1998
- Protection of mice against gastric colonization by Helicobacter pylori by single oral dose immunization with attenuated Salmonella typhimurium producing urease subunits A and BVaccine, 1998
- Mice are protected from Helicobacter pylori infection by nasal immunization with attenuated Salmonella typhimurium phoPc expressing urease A and B subunits.1998
- Vaccine development against infection with Helicobacter pyloriBritish Medical Bulletin, 1998