Molecular Insights into Hypertrophic Cardiomyopathy

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Abstract
Although sporadic descriptions of hypertrophic cardiomyopathy were published as early as 1869 in France1 and 1907 in Germany,2 it was not until the mid-20th century that a comprehensive picture of this disorder began to take shape.3 4 5 In the ensuing four decades, hypertrophic cardiomyopathy has been a trial and a tribulation to researchers and clinicians alike. The trial has been to discern the cause of the often prodigious cardiac hypertrophy, the hallmark of the disorder; the tribulation, to care for afflicted patients, typically young people who are at risk of dying suddenly before reaching the prime of life.6 Recent inquiries into . . .

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