GALACTOSE CATARACT PREVENTION WITH SORBINIL, AN ALDOSE REDUCTASE INHIBITOR - A LIGHT MICROSCOPIC STUDY
- 1 January 1982
- journal article
- research article
- Vol. 22 (2) , 174-179
Abstract
Cataract formation in galactosemic rats was studied by ophthalmoscopy, slit-lamp biomicroscopy, and by light microscopy using plastic embedding with methacrylate. Untreated rats developed nuclear cataracts by 14 days and mature cataracts by 21 days. Rats treated with the aldose reductase inhibitor sorbinil did not develop any cataractous change for up to 8 mo. of 50% galactose feeding and could not be distinguished from normal controls. Apparently, aldose reductase is the common factor involved in the formation of sugar cataracts.This publication has 4 references indexed in Scilit:
- Effect of gossypin, a flavonoid, on the formation of galactose-induced cataracts in ratsExperimental Eye Research, 1979
- Diminished sugar cataractogenesis by quercetinExperimental Eye Research, 1979
- Diabetic Cataracts and FlavonoidsScience, 1977
- Polyol Accumulation in Galactosemic and Diabetic Rats: Control by an Aldose Reductase InhibitorScience, 1973