Guanylate Cyclase and Cyclic-GMP Phosphodiesterase Activities in Mammary Glands of Mice during Pregnancy and Lactation

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Abstract
Guanylate cyclase and cyclic-GMP phosphodiesterase activities were measured in homogenates of mammary glands from virgin, pregnant and lactating mice. Guanylate cyclase activities increased 35% in mammary tissues during pregnancy, and a further 40% increase was observed during lactation. Cyclic-GMP phosphodiesterase activity also increased during pregnancy but activities were not different in glands from lactating mice vs. glands from pregnant mice. These results are discussed with regard to a possible role of cyclic-GMP in regulating lactational processes.

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