Stochastic theory of ligand migration in biomolecules.
- 1 January 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (1) , 26-29
- https://doi.org/10.1073/pnas.75.1.26
Abstract
When ligand binding to proteins involves the presence of more than one ligand inside a given biomolecule, linear deterministic rate equations become useless. A stochastic approach, however, permits a treatment of the migration and binding of small molecules to proteins even at high ligand concentrations. An appropriate linear master equation and its analytic solution are given. As an example, the binding of carbon monoxide to myoglobin at partial pressures from 1 to 10(3) bars (0.1 to 100 MPa) is treated.This publication has 2 references indexed in Scilit:
- Low-temperature flash photolysis studies of cytochrome oxidase and its environmentBiochimica et Biophysica Acta (BBA) - Bioenergetics, 1977
- Dynamics of ligand binding to myoglobinBiochemistry, 1975