RESPONSES OF HYPOPHYSECTOMIZED RATS TO STRESS

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Abstract
SUMMARY: Rats stressed by swimming in cold water (15° C) show a considerably decreased uptake of 32P by the thyroid gland, which is comparable with the decrease in the uptake of 131I. The 32P uptake of the adrenals is increased. These changes are independent of the anterior lobe of the pituitary, since they also occur after hypophysectomy. It is assumed that they are caused by the increased production of vaso-constrictor substances, since treatment with adrenaline produced identical changes in the function of thyroid and adrenals in both intact and hypophysectomized rats. The significance of these changes in formulating a concept of the physiological reaction of the organism to conditions of stress is discussed.

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