BBB Transport and P-glycoprotein Functionality Using MDR1A (-/-) and Wild-Type Mice. Total Brain Versus Microdialysis Concentration Profiles of Rhodamine-123
- 1 January 1998
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 15 (11) , 1657-1665
- https://doi.org/10.1023/a:1011988024295
Abstract
Purpose. The effect of P-glycoprotein (Pgp) on brain distribution using mdrla (-/-) mice was investigated. Methods. Fluorescein (Flu) and FD-4 were used to check whether blood-brain barrier (BBB)...Keywords
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