Pharmacokinetics of dexamethasone and its phosphate ester
- 1 May 1987
- journal article
- research article
- Published by Wiley in Biopharmaceutics & Drug Disposition
- Vol. 8 (3) , 205-212
- https://doi.org/10.1002/bdd.2510080302
Abstract
Dexamethasone in form of its phosphate was given intravenously in two different doses (1.5mg kg−1 and 15 mg). Plasma levels of the ester and dexamethasone were measured and pharmacokinetic parameters were calculated. The results indicate no dose‐dependency of the pharmacokinetic parameters in the investigated range for dexamethasone. Conversion from the prodrug to the active form was rapid; maximum dexamethasone plasma concentrations were reached after 10 min. The results were verified by dexamethasone level monitoring in patients after chronic dosing. Predicted and achieved steady state levels agreed well.Keywords
This publication has 14 references indexed in Scilit:
- HPLC determination of glucocorticoid alcohols, their phosphates and hydrocortisone in aqueous solutions and biological fluidsJournal of Pharmaceutical and Biomedical Analysis, 1986
- Pharmacokinetics of prednisolone after high doses of prednisolone hemisuccinateBiopharmaceutics & Drug Disposition, 1985
- Pharmacokinetics of triamcinolone acetonide and its phosphate esterEuropean Journal of Clinical Pharmacology, 1985
- Effect of smoking on prednisone, prednisolone, and dexamethasone pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1981
- Disposition of synthetic glucocorticoids I. Pharmacokinetics of dexamethasone in healthy adultsJournal of Pharmacokinetics and Biopharmaceutics, 1979
- Bioavailability of dexamethasone; II. Dexamethasone phosphateClinical Pharmacology & Therapeutics, 1975
- Bioavailability of oral dexamethasoneClinical Pharmacology & Therapeutics, 1975
- Comparison of absorption, disposal, and activity of soluble and repository corticosteroid estersClinical Pharmacology & Therapeutics, 1969