Pergolide elevation of MHPG sulphate concentration in rat hypothalamus blocked by spiperone and mimicked by other dopamine agonists

Publisher Website
Google Scholar
Abstract
Pergolide increased the concentration of MHPG sulphate (3-methoxy-4-hydroxy-phenylethylene glycol sulphate) in rat hypothalamus, and the increase was prevented by pretreatment with spiperone, a dopamine antagonist. An increase in hypothalamic MHPG sulphate concentration similar to that caused by pergolide was found after injection of quinpirole, a ‘partial ergoline’ that is a selective D2 agonist not affecting α-adrenoceptors, and by (-)- N-propylnorapomorphine, a dopamine agonist not related to the ergolines. Although the increase in MHPG sulphate concentration produced by pergolide had earlier been assumed to result from blockage of α-adrenoceptors, the present data indicate that it is an effect produced by dopamine D2 receptor stimulation.

This publication has 15 references indexed in Scilit: