Poliomyelitis. III. Propagation of MEFl Strain of Poliomyelitis Virus in Developing Chick Embryo by Allantoic Cavity Inoculation.

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Abstract
Data describing the cultivation of the MEF1 Lansing type poliomyelitis virus in the developing chick embryo are reported. This strain of poliomyelitis virus was derived from the original MEF1 strain following its adaptation to suckling hamsters. Neutralization tests performed at 3 passage levels with bona fide immune hamster and monkey sera prepared against three homotypic strains of the Lansing type virus point to the identity of the chick embryo adapted and propagated virus with this type of poliomyelitis agents. A moderate neutralization has also been shown to take place between the chick embryo adapted virus and immune monkey Brunhilde and Leon sera, but, as indicated, it is difficult to attribute much significance to this finding at the present time. Some exptl. evidence was obtained indicating that the chick embryo-adapted virus does not induce paralysis or death in Rhesus monkeys even following intracerebral inoculation with comparatively massive doses of virus.

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