Effect of pH changes on the cardiac sphincter
- 1 October 1969
- Vol. 10 (10) , 852-856
- https://doi.org/10.1136/gut.10.10.852
Abstract
In 16 normal subjects the pressure characteristics of the cardiac sphincter have been examined. The effect of perfusing the gastric aspect of the sphincter mucosa has been studied by comparing the effects of saline with those of solutions where pH ranged from 1·0 to 8·0. Acid perfusion produced an increase in sphincteric pressure, particularly at pH 3·0. This suggests that a physiological mechanism exists which can increase the barrier pressure to gastrooesophageal reflux during periods of active secretion of the stomach, as occurs in digestion.Keywords
This publication has 8 references indexed in Scilit:
- THE INTRINSIC SPHINCTER IN THE PREVENTION OF GASTRO-ŒSOPHAGEAL REFLUXThe Lancet, 1963
- The Effect of Sympathectomy, Vagotomy, and Oesophageal Interruption on the Canine Gastro-oesophageal SphincterThorax, 1962
- ESOPHAGEAL MOTILITY AFTER VAGOTOMY, PHRENICOTOMY, MYOTOMY, AND MYOMECTOMY IN DOGS1962
- The cardiac sphincter in the catGut, 1961
- Effect of Autonomic Drugs on Gastroesophageal RefluxGastroenterology, 1960
- Regurgitation in anaesthesia: A report on some exploratory work with animalsCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1959
- COMPARISON OF CARDIAC AND PYLORIC SPHINCTERSThe Lancet, 1957
- The Gastroesophageal Sphincter in Healthy Human BeingsDigestion, 1956