Effect of flunixin meglumine on prostaglandin F2α synthesis and metabolism in the pig
- 1 September 1989
- journal article
- research article
- Published by Wiley in Journal of Veterinary Pharmacology and Therapeutics
- Vol. 12 (3) , 307-311
- https://doi.org/10.1111/j.1365-2885.1989.tb00676.x
Abstract
The effect of flunixin meglumine on prostaglandin synthesis and metabolism was evaluated in the pig in vivo. It was found that the prostaglandin metabolite, 15-ketodihydro-PGF2.alpha., was decreased in the peripheral circulation within 20 min of injection of the drug. In therapeutic doses in the pig the drug had no effect on the metabolism of PGF2.alpha.. Flunixin was compared with some other non-steroidal anti-inflammatory drugs in an in vitro test system utilizing sheep vesicular gland microsomes. It was concluded that this drug is a potent inhibitor of prostaglandin synthesis.This publication has 17 references indexed in Scilit:
- Concentrations of Progesterone and 15-Keto-13,14-dihydroprostaglandin F2α in Peripheral Plasma during the Estrous Cycle and Early Pregnancy in Gilts4Zentralblatt für Veterinärmedizin Reihe A, 2010
- Endogenous inhibition of arachidonic acid metabolism in the endometrium of the sheepProstaglandins, Leukotrienes & Essential Fatty Acids, 1989
- Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixinBritish Veterinary Journal, 1987
- Prostaglandin biosynthesis and its regulation in the bovine endometrium: A comparison between nonpregnant and pregnant statusTheriogenology, 1987
- Influence of a physiological infusion of prostaglandin F2α into postpartum cows with partially suppressed endogenous production of prostaglandins. 1. Uterine and ovarian morphological responsesTheriogenology, 1987
- Species differences in circulating prostaglandin metabolites relevance for the assay of prostaglandin releaseBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
- Profiles of prostaglandin metabolites in the human circulationBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1982
- Prostaglandins and ThromboxanesAnnual Review of Biochemistry, 1978
- Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugsBiochemical and Biophysical Research Communications, 1972
- Territoriality in the White Rhinoceros (Ceratotherium simum) BurchellNature, 1971