Indocyanine green clearance in the rhesus monkey (Macaca mulatta)

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Abstract
Plasma clearance rate of lndocyanine green has been determined in 6 rhesus monkeys (Macaca mulatta) equally divided by sex. The results indicate that in the unanesthetized state, the female animals exhibit a slight delay in dye clearance when compared to male animals (P <0.05). The slopes of the clearance curves were found to be exponentially linear throughout the 12-min. sampling period. Pentobarbital anesthesia was shown to significantly delay the clearance rate of indocyanine green in both male and female animals. Biliary recovery of dye was found to be complete within a 5-hr, period and maximal biliary excretion occurred within 2 hr. of dye administration. The arteriohepatic venous extraction ratio of dye ranged between 21 and 41%. Bile flow decreased over a 4-hr. period.