Effects of Dexamethasone and Secobarbital on the Pituitary Response to Thyrotropin Releasing Hormone (TRH) in Man: Synergistic Inhibition of Thyrotropin (TSH) Release

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Abstract
The present study was made to investigate the possible effects of dexamethasone and secobarbital on the pituitary responses of prolactin (PRL) and TSH to TRH. Dexamethasone (1 mg) and secobarbital (100 mg) were administered separately or together at 11 p.m. An intravenous injection of 200 µg TRH was given at 9 a.m. the following morning. PRL control levels and release were not modified by prior administration of the drugs. TSH control levels remained unchanged but TSH release was significantly inhibited by the combined pre-treatment; dexamethasone and secobarbital given alone had no effect. The present study supports the view of a direct synergistic effect of both drugs on the pituitary thyrotropes, diminishing their responsiveness to TRH.

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