Maturation and renal digoxin clearance

Publisher Website
Google Scholar
Abstract
To evaluate the effect of maturation on the renal diposition of digoxin, [an antiarrhythmic agent] the ratio digoxin clearance/creatinine clearance was determined in 35 patients who were 3 days to 79 yr old. All were at steady-state levels for digoxin treatment. A mean ratio of 1.49 .+-. 0.67 was obtained in the group of prepubertal children and infants .gtoreq. 2 mo. of age. The mean ratio decreased to 0.82 .+-. 0.25 in the adult group; adults were defined as sexually mature adolescents or older (P < 0.005). The decrease in net renal tubular secretion of digoxin appears to occur at puberty. Larger doses of digoxin are required by infants and children than by adults. A developmental change in renal tubular physilogy with broader significance than for digoxin disposition alone may exist.

This publication has 6 references indexed in Scilit: